POSITIVE END-EXPIRATORY PRESSURE (PEEP) LEVEL TO PREVENT EXPIRATORY FLOW LIMITATION DURING CARDIAC SURGERY: STUDY PROTOCOL FOR A RANDOMIZED CLINICAL TRIAL (EFLCORE STUDY)

Abstract Background Lung dysfunction commonly occurs after cardiopulmonary bypass (CPB).Randomized evidence suggests that the presence of expiratory flow limitation (EFL) in major abdominal surgery is associated with postoperative pulmonary complications.Appropriate lung recruitment and a correctly set positive end-expiratory pressure (PEEP) level

Leveraging nationally representative survey data on 443,680 respondents from January to March 2021, this study examines the temporal, spatial, and sociodemographic variations in COVID-19 vaccine hesitancy in the U.S.Findings reveal multidimensional determinants of vaccination intentions involving confidence, complacency, and circumspection factors.

The 2016 United Kingdom European Union membership referendum altered the European balance of power, leaving France and Germany as the only major powers in the EU.As a would-be peer within EU institutions, Italy was particularly exposed by this situation and adapted its foreign policy accordingly.Noting that Italy has displayed a mix of cooperation

Von Willebrand Disease (VWD) type 3 is a serious and sometimes fatal hereditary bleeding disorder.In pigs, the disease has been known for decades, and affected animals are used as models for the human disease.Due to the recessive mode of inheritance of VWD type 3, severe bleeding is typically seen in homozygous individuals.We sequenced the complete